BDBM284120 US10023570, Example 130::US10174027, Example 130

SMILES COCCN(C)C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1

InChI Key InChIKey=UVRDHNNVZKOCLZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 284120   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM284120(US10023570, Example 130 | US10174027, Example 130)
Affinity DataIC50:  20.8nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM284120(US10023570, Example 130 | US10174027, Example 130)
Affinity DataIC50:  20.8nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent